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Results there was no significant difference between the control group and the negative control group

Objective To observe the effect of ambroxol and dexamethasone combined with the effects of lipopolysaccharide (LPS) – induced acute lung injury (ALI) in rat pulmonary surfactant protein A (SP-A) expression. Methods 42 SD rats were randomly divided into six groups, 7 rats in each group. nike air max australia Blank control group without treatment, the negative control group from the tail vein injection of normal saline 2 mL. The other four groups were given LPS 5 mg-kg-1, on the basis of ambroxol group given ambroxol hydrochloride 100 mg kg-1, dexamethasone group were treated with dexamethasone 6 mg \/ kg, the combined treatment group received ambroxol 60 mg, 1 + dexamethasone 4 mg-kg-1.

Detected the blood gas analysis index, lung wet dry weight ratio and pathological changes, each SP-A in lung tissue and mRNA expression was determined by immunohistochemistry and RT-PCR. air max australia Results there was no significant difference between the control group and the negative control group (P%26gt; 0.05). And compared to the control group, model group rats arterial blood pH and decrease in PaO2 and lung wet to dry weight ratio increased and SP-A content and mRNA expression decreased, the difference was statistically significant (P% 26lt; 0.05), a clear pathological damage.

With the model group compared the treatment group pH value and PaO2 increased, lung wet to dry weight ratio decreased, SP-A content and mRNA expression were significantly increased (P% 26lt; 0.05), the pathological injury was significantly improved and combined treatment group improved better than the ambroxol hydrochloride group and dexamethasone group (P% 26lt; 0.05).  air max australia cheap Conclusion ambroxol and dexamethasone may have a protective effect on Ali in rats by increasing SP-A in lung tissue, and the two drugs combined with better effect.